Effect of endotoxin and cytokines on lipoprotein lipase activity in mice.

@article{Feingold1994EffectOE,
  title={Effect of endotoxin and cytokines on lipoprotein lipase activity in mice.},
  author={Kennenth R Feingold and Monique Marshall and Rocco Gulli and Arthur H. Moser and Carl Grunfeld},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1994},
  volume={14 11},
  pages={1866-72}
}
Endotoxin (lipopolysaccharide [LPS]) stimulates the production of cytokines, which mediate many of the metabolic effects associated with infection. In LPS-sensitive C57B1/6 mice, LPS doses as low as 0.01 micrograms per mouse decreased adipose tissue lipoprotein lipase (LPL) activity by greater than 50%. In LPS-resistant C3H/HeJ mice, which do not produce cytokines in response to LPS, doses of LPS as high as 10 micrograms per mouse did not affect LPL activity in adipose tissue. In muscle of… CONTINUE READING
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