Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro.

@article{Konopkov2012EffectOE,
  title={Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro.},
  author={R. Konopkov{\'a} and Ildik{\'o} Vil{\'a}gi and S{\'a}ndor Borb{\'e}ly and Hana Kubov{\'a} and Jakub Ot{\'a}hal},
  journal={Physiological research},
  year={2012},
  volume={61 2},
  pages={215-9}
}
Endothelin-1 (ET-1) is a neuroactive protein produced in most brain cell types and participates in regulation of cerebral blood flow and blood pressure. In addition to its vascular effects, ET-1 affects synaptic and nonsynaptic neuronal and glial functions. Direct application of ET-1 to the hippocampus of immature rats results in cerebral ischemia, acute… CONTINUE READING