• DOI:10.1161/01.CIR.81.4.1415
• Corpus ID: 2099436

Effect of endothelin-1 in man.

@article{Vierhapper1990EffectOE,
  title={Effect of endothelin-1 in man.},
  author={Heinrich Vierhapper and Oswald Wagner and Peter J. Nowotny and Werner Waldh{\"a}usl},
  journal={Circulation},
  year={1990},
  volume={81 4},
  pages={
          1415-8
        }
}

• H. Vierhapper, O. Wagner, +1 author W. Waldhäusl
• Published 1 April 1990
• Medicine, Biology
• Circulation

The effect of an intravenous infusion of human endothelin-1 on blood pressure and plasma concentrations of endothelin-1, potassium, sodium, renin, aldosterone, and atrial natriuretic factor was investigated in six healthy, sodium-loaded men. During the peptide's exogenous application (1.0, 2.5, and 5.0 ng/kg.min), its plasma concentrations rose from a basal value of 1.2 +/- 0.3 to 3.2 +/- 1.9, 9.9 +/- 7.6, and 56.5 +/- 50.3 pmol/l (p less than 0.01), respectively, and mean blood pressure rose from a basal value of 87.1 +/- 7.3 to 92.6 +/- 8.2 mm Hg (p less than 0.01). A rise in serum concentrations of potassium (from 4.0 +/- 0.3 to 4.6 +/- 0.2 mmol/l; p less than 0.005) and a concomitant fall in serum concentrations of sodium (from 142.7 +/- 1.0 to 139.5 +/- 2.3 mmol/l; p less than 0.05) was seen in each subject. Plasma concentrations of renin, aldosterone, and atrial natriuretic factor did not change during the infusion of endothelin-1. Thus, in the doses used, endothelin-1 induces a rise in blood pressure and serum potassium concentrations.