Effect of endothelial PAS domain protein 1 and hypoxia inducible factor 1alpha on vascular endothelial growth factor expression in human pancreatic carcinoma.

@article{Zhu2008EffectOE,
  title={Effect of endothelial PAS domain protein 1 and hypoxia inducible factor 1alpha on vascular endothelial growth factor expression in human pancreatic carcinoma.},
  author={Dong-ming Zhu and Dong Mei Li and Zi-xiang Zhang and Xiao-yi Zhang},
  journal={Chinese medical journal},
  year={2008},
  volume={121 22},
  pages={
          2258-64
        }
}
BACKGROUND Transcription factors hypoxia inducible factor 1alpha (HIF 1alpha) and endothelial PAS domain protein 1 (EPAS1) promote the transcription of vascular endothelial growth factor (VEGF). VEGF enhances angiogenesis and vascular permeability of tumours, which promotes tumour growth and facilitates entry of cancer cells into blood circulation and metastasizing. This study examined whether HIF 1alpha and EPAS1 stimulated angiogenesis through activation of VEGF in human pancreatic carcinoma… CONTINUE READING