Effect of endosomal acidification on small ion transport through the anthrax toxin PA63 channel.

@article{Kalu2017EffectOE,
  title={Effect of endosomal acidification on small ion transport through the anthrax toxin PA63 channel.},
  author={Nnanya Kalu and Antonio Alcaraz and Goli Yamini and Sanaz Momben Abolfath and Laura Lucas and Clare Kenney and Vicente M Aguilella and Ekaterina M. Nestorovich},
  journal={FEBS letters},
  year={2017},
  volume={591 21},
  pages={3481-3492}
}
Tight regulation of pH is critical for the structure and function of cells and organelles. The pH environment changes dramatically along the endocytic pathway, an internalization transport process that is 'hijacked' by many intracellularly active bacterial exotoxins, including the anthrax toxin. Here, we investigate the role of pH on single-channel… CONTINUE READING