Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells.

@article{Bonazzi2000EffectOE,
  title={Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells.},
  author={Albino Bonazzi and Manlio Bolla and Carola Buccellati and Arturo Hernandez and Simona Zarini and Teresa Vigan{\'o} and Francesca Fumagalli and Serena Viappiani and Saula Ravasi and Piero Zannini and Gaia Chiesa and Giancarlo Folco and Angelo Sala},
  journal={American journal of respiratory and critical care medicine},
  year={2000},
  volume={162 6},
  pages={2272-7}
}
We studied the effect of endogenous and exogenous prostaglandin E(2) (PGE(2)), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 beta-induced COX-2 expression, using primary cultures of human bronchial smooth-muscle cells (HBSMC). Treatment with exogenous PGE(2) resulted in enhanced expression of IL-1 beta-induced COX-2 protein and messenger RNA (mRNA) as compared with the effect of the cytokine per se. Inhibition of PGE(2) production with a… CONTINUE READING

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