Effect of enamel matrix derivative on the differentiation of C2C12 cells.

@article{Ohyama2002EffectOE,
  title={Effect of enamel matrix derivative on the differentiation of C2C12 cells.},
  author={Mariko Ohyama and Naoto Suzuki and Yoko Yamaguchi and Masao Maeno and Kichibee Otsuka and Koichi Ito},
  journal={Journal of periodontology},
  year={2002},
  volume={73 5},
  pages={543-50}
}
BACKGROUND Although enamel matrix derivative (EMD) can initiate de novo cementum and bone formation by stimulating and inducing differentiation of mesenchymal cells in the periodontal ligament, the molecular mechanism of this phenomenon is not fully understood. The purpose of this study was to determine the effect of EMD on the differentiation of pluripotential mesenchymal cells. METHODS A typical pluripotential mesenchymal cell line, C2C12, was used to clarify the effect of EMD on cell… CONTINUE READING