Effect of enalapril and losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gene.

@article{Trevelyan2004EffectOE,
  title={Effect of enalapril and losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gene.},
  author={Jasper Trevelyan and David J. Brull and Edward W A Needham and Hugh E. Montgomery and Alan Morris and Raj K Mattu},
  journal={The American journal of cardiology},
  year={2004},
  volume={94 5},
  pages={564-9}
}
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may have anti-inflammatory actions, an effect that could explain some of their beneficial effects on cardiovascular events in clinical trials. Coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and provides a convenient model to examine the effects of such agents. Genetic polymorphisms may be important in influencing the expression of cytokines, such as interleukin-6 (IL-6). We… CONTINUE READING

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