Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells.

@article{Hawcroft2010EffectOE,
  title={Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells.},
  author={Gillian Hawcroft and Paul M. Loadman and Andrea Belluzzi and Mark A. Hull},
  journal={Neoplasia},
  year={2010},
  volume={12 8},
  pages={
          618-27
        }
}
The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), in the free fatty acid (FFA) form, has been demonstrated to reduce adenoma number and size in patients with familial adenomatous polyposis. However, the mechanistic basis of the antineoplastic activity of EPA in the colorectum remains unclear. We tested the hypothesis that EPA-FFA negatively modulates synthesis of and signaling by prostaglandin (PG) E(2) in human colorectal cancer (CRC) cells. EPA-FFA induced apoptosis of… Expand
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Exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of P GE(3), and PGE (3)-mediated inhibition of tumor cell proliferation. Expand
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