Effect of early glucocorticoid treatment on MR and GR in late gestation ovine kidney.

@article{Hantzis2002EffectOE,
  title={Effect of early glucocorticoid treatment on MR and GR in late gestation ovine kidney.},
  author={Vicky Hantzis and Anthony Lloyd Albiston and Duana Matsacos and E. Marelyn Wintour and Arianne Peers and Irene Koukoulas and Kathy Myles and Karen Moritz and Miodrag Dodic},
  journal={Kidney international},
  year={2002},
  volume={61 2},
  pages={405-13}
}
BACKGROUND The ontogeny of the renal mineralocorticoid (MR) and glucocorticoid (GR) receptors in the ovine fetus, and the effects of early exposure to synthetic or natural glucocorticoids on the expression of these genes in late gestation were examined. METHODS A partial cDNA sequence for the ovine MR was cloned and used to generate primers and probes to measure MR mRNA expression by real-time polymerase chain reaction (PCR). GR mRNA was also measured. Kidneys were collected from ovine… CONTINUE READING

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