Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects

@article{Lasta2008EffectOD,
  title={Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects},
  author={Michael Lasta and Hemma Resch and Katharina Karl and Guenther Weigert and Michael Wolzt and Anton Hommer and Leopold Schmetterer and Gerhard Garh{\"o}fer},
  journal={BMC Pharmacology},
  year={2008},
  volume={8},
  pages={1}
}
  • Michael Lasta, Hemma Resch, +5 authors Gerhard Garhöfer
  • Published 2008
  • Medicine
  • BMC Pharmacology
  • PURPOSE. Several lines of evidence indicate that altered blood flow regulation may contribute to the pathogenesis of glaucomatous optic neuropathy. Recent data support the hypothesis that the endothelin system is involved in the processes that lead to vascular dysregulation in glaucoma. This study was conducted to test the hypothesis that bosentan, a dual endothelin receptor antagonist, increases ocular blood flow in patients with glaucoma. METHODS. Fourteen patients with primary open-angle… CONTINUE READING

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