Effect of drugs on the uptake of noradrenaline by isolated hypothalamic vesicles.

@article{Philippu1969EffectOD,
  title={Effect of drugs on the uptake of noradrenaline by isolated hypothalamic vesicles.},
  author={A. Philippu and H. Becke and A. Burger},
  journal={European journal of pharmacology},
  year={1969},
  volume={6 2},
  pages={
          96-101
        }
}
Abstract Noradrenaline storing vesicles were isolated from the pig hypothalamus by differential centrifugation, suspended in histidine-HCl buffer and incubated with reserpine, prenylamine or desmethylimipramine. Reserpine and prenylamine (each 6 × 10−5 M) inhibited the ATP-Mg++-dependent uptake of noradrenaline by the vesicles as well as the Ca++ and Mg++ stimulated ATPase. Desmethylimipramine (0.6–60 × 10−8 M) blocked the uptake of catecholamine without influencing the ATPase activity. The… Expand
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