Effect of drugs on the uptake of noradrenaline by isolated hypothalamic vesicles.

@article{Philippu1969EffectOD,
  title={Effect of drugs on the uptake of noradrenaline by isolated hypothalamic vesicles.},
  author={Athineos Philippu and Hellmut Becke and Albrecht Burger},
  journal={European journal of pharmacology},
  year={1969},
  volume={6 2},
  pages={
          96-101
        }
}
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31 Citations

31 Citations

Citation Type

Citation Type

Dopamine and noradrenaline transport into subcellular vesicles of the striatum
TLDR
Incubation with 14C-dopamine or 14C(±)-noradrenaline revealed that the vesicles were able to take up catecholamines by two different transport mechanisms; one was dependent on ATP, magnesium and temperature, the other one was independent of ATP and magnesium, and partially dependent on temperature.
Central effects of sympathomimetic amines on the blood pressure.
Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs.
The effects of a soluble factor and of catecholamines on the activity of adenosine triphosphatase in subcellular fractions of rat brain.
ACTIVE UPTAKE OF [3H]5‐HT BY SYNAPTIC VESICLES FROM RAT BRAIN
TLDR
It was concluded that synaptic vesicles from whole rat brain accumulate [3H]5‐HT by an active process and could not be accounted for by either changes in osmotic pressure or ionic strength.
3H-Dopamine uptake by synaptic storage vesicles of rat whole brain and brain regions.
Uptake of serotonin, gamma-aminobutyric acid and histamine into synaptic vesicles of the pig caudate nucleus
TLDR
It is concluded that the caudate nucles preparation used in this study contains not only dopamine-storing vesicle able to take up biogenic amines but also GABA-containing vesicles which take up GABA by an ATP-magnesium-dependent process.
Stereoselectivity of noradrenaline uptake into synaptic vesicles of the rat brain
TLDR
It is concluded that the ATP-Mg2+-dependent uptake of noradrenaline into synaptic vesicles of the rat brain is stereoselective and that both isomers share the same transport system.
A possible intraneuronal site of action of thymoleptics
TLDR
The results indicate that the inhibition of CA uptake by thymoleptics in the hypothalamus is predominantly due to the inhibition at the synaptic vesicle, while in the striatum the uptake at the synaptosomal membrane is predominantly inhibited.
SYNAPTIC VESICLES ISOLATED FROM RAT HEART: l‐[3H]NOREPINEPHRINE UPTAKE PROPERTIES 1
TLDR
Synaptic vesicles of cardiac sympathetic neurons thus resemble vesicle prepared from other central and peripheral catecholaminergic tissues; this method may be used readily to examine drug effects on rat heart synapticVesicle function.
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References

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