Effect of drugs on the noradrenaline content of brain and peripheral tissues and its significance.

@article{Sanan1962EffectOD,
  title={Effect of drugs on the noradrenaline content of brain and peripheral tissues and its significance.},
  author={S. Sanan and M. Vogt},
  journal={British journal of pharmacology and chemotherapy},
  year={1962},
  volume={18},
  pages={
          109-27
        }
}
  • S. Sanan, M. Vogt
  • Published 1962
  • Medicine
  • British journal of pharmacology and chemotherapy
Large single doses of methoserpidine (12 mg/kg) given to rabbits lowered the noradrenaline content of sympathetic ganglia but not that of brain; no sedation was observed. Cats responded to doses ranging from 12 to 0.5 mg/kg with loss of noradrenaline from ganglia as well as from brain, and were sedated by the drug. The effect in man resembles that in the rabbit. Only within the group of reserpine-like drugs do sedation and loss in hypothalamic noradrenaline run parallel. These effects are… Expand
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