Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants.

@article{Ho2007EffectOD,
  title={Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants.},
  author={Richard Ho and Leena Choi and Wooin Lee and Gail Mayo and Ute I. Schwarz and Rommel G. Tirona and David G Bailey and Charles M. Stein and Richard B Kim},
  journal={Pharmacogenetics and genomics},
  year={2007},
  volume={17 8},
  pages={647-56}
}
OBJECTIVE Our aims were to evaluate the effects of polymorphisms in the hepatic drug uptake transporter organic anion transporting polypeptide 1B1 (OATP1B1, SLCO1B1) and efflux transporters multidrug resistance-associated protein 2 (MRP2, ABCC2), bile salt export pump (BSEP, ABCB11), and breast cancer-related protein (BCRP, ABCG2) on single-dose pravastatin pharmacokinetics in healthy European- and African-American participants. METHODS The pharmacokinetics of a single oral 40 mg dose of… CONTINUE READING

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