Effect of drug resistance on the generation of secondary cases of tuberculosis.

  title={Effect of drug resistance on the generation of secondary cases of tuberculosis.},
  author={Marcos V Burgos and Kathryn Deriemer and Peter M. Small and P. Hopewell and Charles L. Daley},
  journal={The Journal of infectious diseases},
  volume={188 12},
BACKGROUND The results of animal studies suggest that isoniazid-resistant strains of Mycobacterium tuberculosis are less pathogenic than isoniazid-susceptible strains. Here, we assess the relative pathogenicity of drug-resistant and drug-susceptible strains, in a human population. METHODS We linked IS6110 genotype patterns of M. tuberculosis strains with drug-susceptibility test results and epidemiologic information for 85% of culture-positive incident cases of tuberculosis (TB) in San… CONTINUE READING


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Fundamentals of Biostatistics

  • B. Rosner
  • 5th ed. Pacific Grove, CA: Duxbury Thomson…
  • 2000
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