Effect of drug pretreatment on the metabolic oxidation of chlorpromazine in rat.


The metabolic oxidation of chlorpromazine (CPZ) was investigated after pretreatment of rats with some drugs and chemicals for 6 days. Pentobarbitone, gamma-collidine, ethanol, and anthracene induced a significant increase in both S-oxidation and 7-hydroxylation, whereas CPZ pretreatment increased mainly 7-hydroxylation. Metyrapone and safrole preferentially… (More)


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