Effect of drug-induced cytotoxicity on glucose uptake in Hodgkin's lymphoma cells.

@article{Banning2006EffectOD,
  title={Effect of drug-induced cytotoxicity on glucose uptake in Hodgkin's lymphoma cells.},
  author={Ursula Banning and Henryk Barthel and Christine Mauz-K{\"o}rholz and Regine Kluge and Dieter Koerholz and Osama Sabri},
  journal={European journal of haematology},
  year={2006},
  volume={77 2},
  pages={102-8}
}
BACKGROUND In Hodgkin's lymphoma, F-18-fluoro-deoxy-d-glucose positron emission tomography (FDG-PET) is used for staging and response evaluation after chemotherapy. However, drug-mediated downregulation of glucose uptake in viable Hodgkin's lymphoma cells might limit the use of FDG-PET. METHODS We analyzed the effect of etoposide on cell viability and uptake of F-18-fluoro-deoxy-D-glucose or the glucose analog 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxyglucose (2-NBDG) in vitro… CONTINUE READING