Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles.

@article{Panagi2001EffectOD,
  title={Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles.},
  author={Zoi Panagi and A Beletsi and Gregory P. Evangelatos and Evangelia Livaniou and D. S. Ithakissios and Konstantinos Avgoustakis},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={221 1-2},
  pages={143-52}
}
The effect of nanoparticle dose on the biodistribution and pharmacokinetics of conventional PLGA and stealth poly(Lactide-co-glycolide)-monomethoxypoly(ethyleneglycol) (PLGA-mPEG) nanoparticles was investigated. The precipitation-solvent diffusion method was used to prepare PLGA and PLGA-mPEG nanoparticles labeled with 125I-cholesterylaniline. These were administered intravenously (i.v.) in mice and at predetermined time intervals the animals were sacrificed and their tissues were excised and… CONTINUE READING

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