Effect of dose escalation on the tolerability and efficacy of duloxetine in the treatment of women with stress urinary incontinence

@article{Castrodaz2006EffectOD,
  title={Effect of dose escalation on the tolerability and efficacy of duloxetine in the treatment of women with stress urinary incontinence},
  author={david M. Castro-d{\'i}az and Paulo C{\'e}sar Rodrigues Palma and C{\'e}line Bouchard and François Haab and Christian Hampel and Roberto Carone and Sebastian Zepeda Contreras and Henry Rodriguez Ginorio and Simon Voss and Ilker Yalcin and Richard C. Bump},
  journal={International Urogynecology Journal},
  year={2006},
  volume={18},
  pages={919-929}
}
To assess the impact of duloxetine dose escalation on tolerability and efficacy, 516 women with stress urinary incontinence were randomized to receive placebo or duloxetine in one of three regimens: 40 mg BID for 8 weeks, 40 mg QD for 2 weeks escalating to 40 mg BID for 6 weeks or 20 mg BID for 2 weeks escalating to 40 mg BID for 6 weeks. A non-inferiority analysis confirmed that the 20 mg BID starting dose was significantly better than the other two duloxetine regimens for nausea reduction (16… CONTINUE READING

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A randomized controlled trial of duloxetine alone , pelvic floor muscle training alone , combined treatment and no active treatment in women with stress urinary incontinence

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