Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.

@article{Saxena2008EffectOD,
  title={Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.},
  author={Gunjan Saxena and Sheelendra Pratap Singh and Rahul D Agrawal and Chandishwar Nath},
  journal={European journal of pharmacology},
  year={2008},
  volume={581 3},
  pages={283-9}
}
Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer's disease. Presently, cholinesterase inhibitors are the mainstay of therapy for Alzheimer's disease. However, the potential of cholinesterase inhibitors as antioxidants, an important aspect for neuroprotection, has not been properly investigated. Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of… CONTINUE READING
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