Effect of dizocilpine (MK-801) on the catalepsy induced by delta 9-tetrahydrocannabinol in mice.

Abstract

Mice treated with delta 9-tetrahydrocannabinol (THC; 5 and 10 mg/kg i.v.) showed the catalepsy in high bar test, and median descent latencies of catalepsy were about 150 sec. Dizocilpine (MK-801, 0.05 and 0.1 mg/kg), non-competitive N-methyl-D-aspartate (NMDA) antagonist, significantly attenuated THC-induced catalepsy. Furthermore, the anticataleptic effect… (More)

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Cite this paper

@article{Kinoshita1994EffectOD, title={Effect of dizocilpine (MK-801) on the catalepsy induced by delta 9-tetrahydrocannabinol in mice.}, author={Hiroyuki Kinoshita and Tomoko Hasegawa and Yuri Katsumata and Tsutomu Kameyama and Ichiro Yamamoto and Toshitaka Nabeshima}, journal={Journal of neural transmission. General section}, year={1994}, volume={95 2}, pages={137-43} }