Effect of disuse on the ultrastructure of the achilles tendon in rats

  title={Effect of disuse on the ultrastructure of the achilles tendon in rats},
  author={Yoshinao Nakagawa and Manabu Totsuka and Tomoaki Sato and Yoshiro Fukuda and K Hirota},
  journal={European Journal of Applied Physiology and Occupational Physiology},
SummaryWe examined the influence exerted, through disuse of the hindlimb, on the collagen fibres of the achilles tendon in rats. With disuse the body mass decreased by 28%, and the mass of soleus muscle decreased by 20%. A decrease in the surface area and diameter was observed in the experimental group when compared to the control group. A histogram of the collagen fibres showed a decrease of the thick fibres in the experimental group. The maximum surface area of collagen fibres in the… 

Effects of hindlimb unloading and subsequent reloading on the structure and mechanical properties of Achilles tendon‐to‐bone attachment

  • C. CamyT. Brioche S. Roffino
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2022
The study examined the effects of mechanical loading on the structure and mechanical properties of the Achilles tendon enthesis and suggested that care must be taken when performing countermeasure exercises both during missions and during the return to Earth.

The individual and combined effects of exercise and collagenase on the rodent Achilles tendon

Muscle forces directly influence bone adaptation: 1269: Board #5 June 1 9:30 AM – 11:00 AM [Abstract].

Morphological Changes in Disused and Denervated Old Rat Achilles Tendon Fibrils

Under TEM, quantitative analyses of collagen fibril diameters were performed and each explanted Achilles tendon was used for TEM observa- tion.

The influence of physical activity during youth on structural and functional properties of the Achilles tendon

The data suggest that high or low activity during youth did not appreciably influence the mechanical, structural, or biochemical properties of the Achilles tendon in adult long distance runners.

Changes in Cellular and Biomechanical Properties in the Rat Gastrocnemius Muscle Complex Following Injection of Platelet Rich Plasma and Traumeel®S Post Calcaneal Tenotomy

The results of this study indicate that predominantly PRP but also TraumeelS can decrease mean repair tension at four and six weeks post tenotomy, and increase myofibre regeneration and stimulate neotendon regeneration, as well as increase TGF-β1 and b-FGF protein expression within the gastrocnemius muscle and neot tendon.

Obesity Affects Collagen Fibril Diameter and Mechanical Properties of Tendons in Zucker Rats

It is concluded that obesity provokes alterations in the composition and organization of tendon extracellular matrix components, related to organizational and structural modifications in the collagen bundles, influencing the mechanical properties of the tendon and the progression to a pathological state.

Cyclic mechanical stimulation rescues achilles tendon from degeneration in a bioreactor system

  • Tao WangZhen Lin M. Zheng
  • Biology, Engineering
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2015
It is indicated that a proper biomechanical environment was able to rescue early‐stage pathological changes by increased collagen type I production, decreased collagen degradation and cell apoptosis, and the pathological changes and mechanical properties were almost restored to levels seen in healthy tendon.

Reduction in tendon elasticity from unloading is unrelated to its hypertrophy.

It is suggested that, although tendonhypertrophy can be expected to adversely affect tendon stiffness, the absence of any significant correlation between the magnitude of tendon hypertrophy and reduced Young's modulus indicates that dimensional factors were not critical to the elastic properties.



An experimental study of joint stiffness.

  • W. Akeson
  • Biology, Engineering
    The Journal of bone and joint surgery. American volume
  • 1961
Correlation between experimental findings and present concepts of connective-tissue metabolism has led to a hypothesis concerning the mechanism of development of joint contractures.

Effects of suspension hypokinesia/hypodynamia on rat skeletal muscle.

The effects of suspension hypokinesia/hypodynamia (H/H) on properties of soleus and plantaris muscles of rats were compared to those of disuse atrophy to suggest that observed changes were not due to systemic factors.

Structural and functional responses to prolonged hindlimb suspension in rat muscle.

The results suggest that type I fibers showed an earlier and greater susceptibility than type II fibers to suspension which is also accompanied by a decreased aerobic capacity.

Functional Properties of Knee Ligaments and Alterations Induced by Immobilization: A Correlative Biomechanical and Histological Study in Primates

  • F. Noyes
  • Biology, Engineering
    Clinical orthopaedics and related research
  • 1977
The effect of immobility on the biomechanical properties of an anterior cruciate bone-ligament-bone unit of rhesus monkey is reported and a significant alteration in the projected functional capacity of the ligament unit to resist loading and to resist elongation is indicated.

Size and metabolic properties of single muscle fibers in rat soleus after hindlimb suspension.

A shift in the contractile potential of the muscle following HS without a deficit in SDH is suggested, a metabolic property commonly associated with resistance to fatigue, and the view that soleus muscle fibers can change from a slow- twitch oxidative to a fast-twitch oxidative-glycolytic profile is supported.

Effects of simulated weightlessness on bone mineral metabolism.

Changes in local factors within the unweighted bones may have a greater impact on bone mass and turnover than changes in systemic factors that regulate overall bone mineral homeostasis.

Influence of physical activity on ligament insertions in the knees of dogs.

The widespread subperiosteal bone loss consequent to inactivity probably healed in the same way, suggesting on the basis of this histological evidence that inactivity produces bone resorption which is followed by bone accretion.

Biomechanics of ligament failure. II. An analysis of immobilization, exercise, and reconditioning effects in primates.

After eight weeks of immobilization, anterior cruciate bone-ligament-bone preparations of wild primates tested in tension showed significant decreases in maximum failure load and energy absorbe.

Rat hindlimb muscle responses to suspension hypokinesia/hypodynamia.

H/H suspended rats failed to grow; following removal from suspension they gained weight linearly, comparable to controls; products of muscle metabolism including urea, ammonia, and 3-methylhistidine increased in the urine during H/H suspension and were significantly reduced approaching control levels during recovery.

Activity influences on soleus muscle myosin during rodent hindlimb suspension.

In the context of the hindlimb unweighting model, the mechanisms controlling the expression of soleus muscle SM and fast myosin genes can be affected differently by the diverse activities of stationary ground support, unrestricted cage activity, and programmed uphill running.