Corpus ID: 29943902

Effect of disulfiram on function of the liver of rats with galactosamine-induced hepatitis.

  title={Effect of disulfiram on function of the liver of rats with galactosamine-induced hepatitis.},
  author={T. Mach},
  journal={Polish journal of pharmacology and pharmacy},
  volume={38 3},
  • T. Mach
  • Published 1986
  • Medicine
  • Polish journal of pharmacology and pharmacy
This study was aimed to examine whether disulfiram (DS) may exacerbate the pre-existing liver damage induced by D-galactosamine (GalN) in rats. DS, 600 mg/kg, administered by gavage for 3 days caused an increase in asparagine aminotransferase (AspAT) and alkaline phosphatase (AP) and a decrease in cholinesterase (ChE) activity in the serum and decrease in AspAT and ChE activity in the liver. DS given to rats with GAlN-induced liver injury caused significant increase in alanine aminotransferase… Expand
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