Effect of disruption of Staphylococcus aureus PBP4 gene on resistance to beta-lactam antibiotics.

@article{Katayama2003EffectOD,
  title={Effect of disruption of Staphylococcus aureus PBP4 gene on resistance to beta-lactam antibiotics.},
  author={Yuki Katayama and Hong-zhong Zhang and Henry F. Chambers},
  journal={Microbial drug resistance},
  year={2003},
  volume={9 4},
  pages={329-36}
}
Penicillin-binding proteins (PBPs) mediate susceptibility to beta-lactam antibiotics. PBP 4, although not essential for survival, has been associated with low-level resistance to beta-lactam antibiotics. To determine its contribution to survival of Staphylococcus aureus cells exposed to beta-lactams, the PBP 4 gene (pbp4) was disrupted and then complemented in the methicillin-susceptible strain RN4220 and the homogeneous methicillin-resistant strain COL. Depending on the antibiotic tested, the… CONTINUE READING

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