Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: A quantitative analysis

@article{Bezzina2008EffectOD,
  title={Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: A quantitative analysis},
  author={G. Bezzina and S. Body and T. Cheung and C. Hampson and C. Bradshaw and E. Szabadi and I. Anderson and J. Deakin},
  journal={Behavioural Brain Research},
  year={2008},
  volume={191},
  pages={272 - 279}
}
  • G. Bezzina, S. Body, +5 authors J. Deakin
  • Published 2008
  • Psychology, Biology, Medicine
  • Behavioural Brain Research
  • Previous experiments showed that destruction of the orbital prefrontal cortex (OPFC) or the nucleus accumbens core (AcbC) in rats altered choice between two delayed food reinforcers. Application of a quantitative model of inter-temporal choice suggested that lesions of either structure increased the delay-dependent degradation of reinforcer value (delay discounting); destruction of the OPFC (but not the AcbC) also increased the relative value of the larger reinforcer. This experiment examined… CONTINUE READING
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