Effect of dipyrone, L-NAME and L-arginine on endotoxin-induced rat paw edema.

Abstract

Paw edema was induced in male Wistar rats (200-250 g) by intraplantar (ipl) administration of 2.5 micrograms endotoxin (Etx). Etx, like carrageenin, produced two distinct edema formation phases, an early phase (75 min) followed by a late phase (7 h). We showed that the edema formation in the early phase was antagonized by dipyrone (80 mg/kg, i.p.) and… (More)

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@article{Fracasso1996EffectOD, title={Effect of dipyrone, L-NAME and L-arginine on endotoxin-induced rat paw edema.}, author={Jos{\'e} F. Fracasso and R. L. Nunes-de-Souza and Cleber E. Teixeira and R{\'e}gia Christina Moura Barbosa Castro and Eugenia Lepera and R. S. S. F. Silva}, journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas}, year={1996}, volume={29 11}, pages={1543-8} }