Effect of diphenylhydantoin on drug and calcium induced contractions of isolated rat uterus: a comparative study with nifedipine.

@article{Calixto1987EffectOD,
  title={Effect of diphenylhydantoin on drug and calcium induced contractions of isolated rat uterus: a comparative study with nifedipine.},
  author={Jo{\~a}o Batista Calixto},
  journal={General pharmacology},
  year={1987},
  volume={18 3},
  pages={237-43}
}
The sustained contractions induced by K+, acetylcholine (ACh) and oxytocin (Ot) were inhibited in a concentration-dependent fashion by diphenylhydantoin (DPH) and nifedipine (NIF) in the following order of sensitivity: K+ greater than ACh greater than Ot. Previous incubation of DPH and NIF produced a non-competitive antagonism towards ACh and Ot-induced… CONTINUE READING