Effect of dimethylthiourea on paraquat toxicity in rats.

  title={Effect of dimethylthiourea on paraquat toxicity in rats.},
  author={Ronald D. Fairshter and Nosratola D. Vaziri and Lyle C. Dearden and Kevin Malott and Marjorie C. Caserio},
  journal={Toxicology and applied pharmacology},
  volume={74 1},
We evaluated the utility of dimethylthiourea ( DMTU ), a hydroxyl radical scavenger, as potential therapy for paraquat poisoning. Seventy-five male Sprague-Dawley rats were divided into four groups ( DMTU -paraquat, paraquat, DMTU , control) and studied for up to 10 days. Clinical observations (dyspnea, weakness), mortality, hepatic and renal function tests, body weights, and histologic studies were performed. There was no mortality in the DMTU and control groups although various histologic and… Expand
Effect of dimethylthiourea on plasma paraquat concentration.
Plasma biochemical studies indicated that paraquat caused hyperglycemia as well as an early reduction (compared to controls) in hepatic enzymes and impaired synthesis or inhibition of release of hepatic proteins may be an early effect of paraquats. Expand
Failure of desferrioxamine to modify the toxicity of paraquat in rats.
Surprisingly, results when both PQ++ and DF were administered indicated a failure of DF to ameliorate toxic effects of PQ ++ in the lung, and even suggested an accentuation of P Q++-induced damage by DF. Expand
It appears that some of the drugs used may be effective in reversing PQ-induced poisoning in mice and possibly their effects are related to the inhibition of membrane lipid peroxidation via different mechanisms. Expand
Potentiation of oxidant-induced toxicity in hamster lung slices by dimethylthiourea.
The toxicity of oxidants toward lung tissue is potentiated in alveolar epithelial cells by DMTU, suggesting that at the high concentration, D MTU may cause functional impairment of the tissue. Expand
Dimethylthiourea protects rats against gram-negative sepsis and decreases tumor necrosis factor and nuclear factor kappaB activity.
The results suggest that the protective effect of DMTU in gram-negative bacterial sepsis may be the result of a reduction in TNF activity. Expand
Accentuation of paraquat‐induced toxicity by L‐carnitine in mice
Results indicate that L‐carnitine accelerates PQ‐induced mortality rate by facilitating lipid peroxidation. Expand
Evidence for hydroxyl free radical formation during paraquat but not for nifurtimox liver microsomal biotransformation. A dimethyl-sulfoxide scavenging study
The low temperature gas chromatographic separation of d3-CH4 from CH4 described opens the future possibility for detecting trace formation of ·OH in vivo, without interference from fecal CH4 formation by administering d6-DMSO to animals and collecting exhaled gases produced, in chambers containing the entire animal. Expand
Epithelial injury induced by exposure to residual oil fly-ash particles: role of reactive oxygen species?
In vitro findings suggest that ROFA-induced RTE cell injury may be mediated by hydroxyl-radical-like reactive oxygen species (i.e., species scavenged by DMTU) that are generated via non-nitric oxide pathways. Expand
Artemia salina as a test organism for measuring superoxide-mediated toxicity.
  • R. Matthews
  • Biology, Medicine
  • Free radical biology & medicine
  • 1995
It is found that Artemia salina are extremely sensitive to menadione bisulfite, a compound whose toxicity is probably mediated by intracellular superoxide generation. Expand
Amelioration of retinal photic injury in albino rats by dimethylthiourea.
It is demonstrated that dimethylthiourea penetrates well into retinal tissue and has a half-life of approximately 19 hours, and that hydroxyl radical plays an important role in mediating retinal photic injury. Expand


A mechanism of paraquat toxicity in mice and rats.
The cross-tolerance of oxygen and paraquats and the induction by paraquat of pulmonary enzymes that supply reducing equivalents to combat oxidative damage support the proposal that paraqu at may initiate lipid peroxidation in vivo. Expand
Nephrotoxicity of paraquat in the sheep and the associated reduction in paraquat secretion.
  • D. Webb
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1983
Paraquat was administered to sheep at doses of 1, 2, 4, and 8 mg/kg, producing glomerular and tubular defects and poisoning of the secretory component removed a large part of the excretory capacity for paraquat. Expand
Ultrastructural evidence of pulmonary capillary endothelial damage from paraquat.
Alveolar epithelial injury and damage to pulmonary capillary endothelium seems to be a factor favoring paraquat-induced pulmonary edema, although other mechanisms are probably important. Expand
Ascorbic acid and paraquat: oxygen depletion with concurrent oxygen activation.
The results suggest that the previously reported in vivo potentiation of paraquat toxicity by ascorbate may be related to either a decreased subcellular oxygen availability, or the presence of activated oxygen species, or (3) both. Expand
Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.
Two lines of investigation supported the premise that killing of Staphylococcus aureus, 502A, by hydrogen peroxide involves formation of the more toxic hydroxyl radical (.OH) through theExpand