Effect of dimethylthiourea on paraquat toxicity in rats.

@article{Fairshter1984EffectOD,
  title={Effect of dimethylthiourea on paraquat toxicity in rats.},
  author={Ronald D. Fairshter and Nosratola D. Vaziri and Lyle C. Dearden and Kevin Malott and Marjorie C. Caserio},
  journal={Toxicology and applied pharmacology},
  year={1984},
  volume={74 1},
  pages={
          150-4
        }
}
We evaluated the utility of dimethylthiourea ( DMTU ), a hydroxyl radical scavenger, as potential therapy for paraquat poisoning. Seventy-five male Sprague-Dawley rats were divided into four groups ( DMTU -paraquat, paraquat, DMTU , control) and studied for up to 10 days. Clinical observations (dyspnea, weakness), mortality, hepatic and renal function tests, body weights, and histologic studies were performed. There was no mortality in the DMTU and control groups although various histologic and… Expand
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