Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on fatty liver induced by carbon tetrachloride.

@article{Imaizumi1981EffectOD,
  title={Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on fatty liver induced by carbon tetrachloride.},
  author={Yoshinori Imaizumi and Tatsuyoshi Sugimoto and Takao Kasai},
  journal={Japanese journal of pharmacology},
  year={1981},
  volume={31 1},
  pages={
          15-21
        }
}
The therapeutic effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the fatty liver induced by carbon tetrachloride (CCl4) was studied. The recovery from elevated liver triglyceride levels induced by CCl4 required over 20 days in 35 week-old rats, but 14 days in 6 week-old rats. This indicates that 35 week-old rats are useful for studying the therapeutic effect of NKK-105 on fatty liver. In rats with CCl4-induced fatty liver, NKK-105 lowered the hepatic triglyceride level… 
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Action of malotilate on reduced serum cholesterol level in rats with carbon tetrachloride-induced liver damage.
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NKK-105 significantly decreased the acuteoxicity of these drugs but the inhibitory effect was not observed in the acute toxicity of atropine, tetrodotoxin, lead acetate and arsenic trioxide.
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