Effect of dihydroergosine (DHESN) on the serotoninergic system and behaviour: Is DHESN a new antidepressive agent?

@article{Perii1986EffectOD,
  title={Effect of dihydroergosine (DHESN) on the serotoninergic system and behaviour: Is DHESN a new antidepressive agent?},
  author={Danka Peri{\vc}i{\'e} and Hari Manev and Sonja Levanat and B Jernej and Dunja Vuji{\'c} and Neboj{\vs}a M. Djordjevic},
  journal={Psychopharmacology},
  year={1986},
  volume={90},
  pages={112-118}
}
  • Danka Peričié, Hari Manev, +3 authors Nebojša M. Djordjevic
  • Published 1986
  • Psychology, Medicine
  • Psychopharmacology
  • Acute (50.0 mg/kg) and repeated (0.1–10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rats DHESN enhanced the 5-HT/5-HIAA ratio. DHESN administered to rats repeatedly over 5 days decreased the level of 5-HT in blood platelets, and in vitro at concentrations of 10-4 M… CONTINUE READING

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