Effect of different pulses of nitric oxide on venous admixture in the anaesthetized horse.

@article{Heinonen2002EffectOD,
  title={Effect of different pulses of nitric oxide on venous admixture in the anaesthetized horse.},
  author={Erkki Heinonen and G{\"o}rel Nyman and Pekka Meril{\"a}inen and Marieann H{\"o}gman},
  journal={British journal of anaesthesia},
  year={2002},
  volume={88 3},
  pages={
          394-8
        }
}
BACKGROUND Dependent atelectatic lung areas open towards the end of inspiration when the lung opening pressure increases, and recollapse during expiration. We hypothesized that inhaled nitric oxide (NO) counteracts hypoxic vasoconstriction in these collapsing lung areas, resulting in increased pulmonary shunt perfusion. METHODS We administered NO as a pulse and varied the pulse timing during inspiration in equine anaesthesia, where atelectasis develops regularly. Six spontaneously breathing… CONTINUE READING

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