Effect of different penetration enhancers on diclofenac permeation across horse skin.

Abstract

Diclofenac is a hydrophilic non-steroidal anti-inflammatory drug widely used in humans and animals. Previous reports have shown that this compound has low percutaneous absorption in horses. The effect of five penetration enhancers (10% urea, 15% and 20% oleic acid and 5% and 10% d-limonene) on the percutaneous absorption of diclofenac diethylamine through… (More)
DOI: 10.1016/j.tvjl.2009.09.010

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