Effect of different ozone concentrations on the neurogenic contraction and relaxation of guinea pig airways.

@article{Sommer1997EffectOD,
  title={Effect of different ozone concentrations on the neurogenic contraction and relaxation of guinea pig airways.},
  author={Bettina Sommer and Mario H. Vargas and Patricia Segura and Blanca Baz{\'a}n-Perkins and Ver{\'o}nica Carbajal and Jaime Ch{\'a}vez and Pascal Gustin and Luis M Monta{\~n}o},
  journal={Fundamental & clinical pharmacology},
  year={1997},
  volume={11 6},
  pages={501-11}
}
Prejunctional and postjunctional effects of several ozone (O3) concentrations, including those found in highly polluted cities, were evaluated in guinea pig airways. Animals bred in O3-free conditions were exposed to air or O3 (0.3, 0.6 or 1.2 ppm) during 4 h, and studied 16-18 h later. Tracheal and bronchial rings were studied in organ baths. Electrical field stimulation (EFS) (100 V, 2 ms, 10 s) was given at increasing frequencies (0.25-16 Hz). Some tissues received atropine (2 microM) and/or… CONTINUE READING