Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine model.

@article{Cheung2006EffectOD,
  title={Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine model.},
  author={Gordon Yiu Chong Cheung and Dorothy K-L Xing and Sandra Prior and Michael J. Corbel and Roger Parton and John Graham Coote},
  journal={Infection and immunity},
  year={2006},
  volume={74 12},
  pages={6797-805}
}
Four recombinant forms of the cell-invasive adenylate cyclase toxin (CyaA) of Bordetella pertussis were compared for the ability to enhance protection against B. pertussis in mice when coadministered with an acellular pertussis vaccine (ACV). The four forms were as follows: fully functional CyaA, a CyaA form lacking adenylate cyclase enzymatic activity (CyaA*), and the nonacylated forms of these toxins, i.e., proCyaA and proCyaA*, respectively. None of these forms alone conferred significant (P… CONTINUE READING
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Acellular pertussis vaccines.

Pediatrics in review • 1998
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