Effect of different dietary protein composition on skeletal muscle atrophy by suspension hypokinesia/hypodynamia in rats.

@article{Tada2002EffectOD,
  title={Effect of different dietary protein composition on skeletal muscle atrophy by suspension hypokinesia/hypodynamia in rats.},
  author={Osamu Tada and Hidehiko Yokogoshi},
  journal={Journal of nutritional science and vitaminology},
  year={2002},
  volume={48 2},
  pages={
          115-9
        }
}
  • O. Tada, H. Yokogoshi
  • Published 1 April 2002
  • Biology, Medicine
  • Journal of nutritional science and vitaminology
Under microgravity conditions similar to those in space, it is known that various nutritional and physiological changes in the body are induced. Especially in the aspect of nutrition, muscle atrophy is a characteristic phenomenon accompanying weightlessness. This study was conducted to investigate the ameliorated effect of muscle atrophy caused by suspension hypokinesia by using the soy protein isolate (SPI) as the protein source in comparison with casein. Male Wistar strain rats (8 wk old… 
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Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling.
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Effects of Suspension Hypokinesia/Hypodynamia on the Body Weight and Nitrogen Balance in Rats Fed with Various Protein Concentrations
Hypokinesia/hypodynamia was induced in the hindlimbs of rats by means of a suspension harness, and metabolic balance studies, especially regarding nitrogen, were performed with different dietary
Effect of suspension hypokinesia/hypodynamia on tissue protein turnover in rats.
TLDR
Both the increased catabolism and decreased synthesis of protein in the muscles may be causally related to the muscle atrophy occurring in suspension, which may explain, at least partly, the slightly positive nitrogen balance which was observed after long-term weightlessness.
A model for hypokinesia: effects on muscle atrophy in the rat.
TLDR
It was concluded that significant muscle atrophy and parallel changes in nitrogen metabolism occur in suspended rats and these changes are readily reversible.
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Effects of Suspension Hypokinesia/Hypodynamia on Morphometric Measurements of Rat Muscle Fibers
The effect of simulated weightlessness on the morphological and histochemical changes of skeletal muscles was investigated, using a suspension harness, for 10 days. The weights of the gastrocnemius
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TLDR
Changes in local factors within the unweighted bones may have a greater impact on bone mass and turnover than changes in systemic factors that regulate overall bone mineral homeostasis.
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TLDR
It was concluded that heavy-resistance training results in increases in muscle energy reserves which may be reversed by a period of immobilization-induced disuse.
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TLDR
According to measurements in incubated epitrochlearis muscles, dexamethasone-induced muscle wasting mainly resulted from increased protein breakdown in the adult, but from depressed protein synthesis in the aged animal, suggesting that glucocorticoids may be involved in the emergence of muscle atrophy with advancing age.
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