Effect of different arginine methylations on the thermodynamics of Tat peptide binding to HIV-1 TAR RNA.

@article{Kumar2013EffectOD,
  title={Effect of different arginine methylations on the thermodynamics of Tat peptide binding to HIV-1 TAR RNA.},
  author={Santosh Kumar and Souvik Maiti},
  journal={Biochimie},
  year={2013},
  volume={95 7},
  pages={1422-31}
}
RNA-binding proteins are an important class of mediators that regulate cell function and differentiation. Methylation of arginine, a post-translational modification (PTM) found in these proteins, can modulate their function. Arginine can be monomethylated or dimethylated, depending on the type of methyl transferases involved. This paper describes a comparative study of the thermodynamics of unmodified and modified Tat peptide interaction with TAR RNA, where the peptide is methylated at epsilon… CONTINUE READING

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