Effect of dietary sodium chloride on insulin receptor number and mRNA levels in rat kidney.

@article{Sechi1994EffectOD,
  title={Effect of dietary sodium chloride on insulin receptor number and mRNA levels in rat kidney.},
  author={Leonardo A Sechi and Cora A Griffin and Morris Schambelan},
  journal={The American journal of physiology},
  year={1994},
  volume={266 1 Pt 2},
  pages={F31-8}
}
Insulin has been postulated to play a role in the pathophysiology of essential hypertension via an antinatriuretic action. To further explain the sodium insulin interaction in the kidney, we studied effects of different salt intakes on insulin receptor binding and mRNA levels in tissues from rats maintained on 0.07%, 0.3%, or 7.5% NaCl for 14 days. Scatchard analysis of competition data from in situ autoradiography studies resulted in curvilinear profiles, indicating the presence of either two… CONTINUE READING

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To further explain the sodium insulin interaction in the kidney , we studied effects of different salt intakes on insulin receptor binding and mRNA levels in tissues from rats maintained on 0.07% , 0.3% , or 7.5% NaCl for 14 days .
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