Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease Study.

@article{Kopple1997EffectOD,
  title={Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease Study.},
  author={Joel David Kopple and Andrew S. Levey and T. V. Greene and Wm. Cameron Chumlea and Jennifer J. Gassman and Donna Hollinger and Bradley J. Maroni and Donna Z. Merrill and L K Scherch and Sarah M. Nordstrom and Sheng Ru Wang and Gabrial S. Zimmer},
  journal={Kidney international},
  year={1997},
  volume={52 3},
  pages={
          778-91
        }
}
The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/day). In Study B, 255 patients with a GFR of 13 to 24 ml/min/1.73 m2 were randomly assigned to the low-protein diet or a very-low-protein diet (0.28 g/kg/day), supplemented with a… CONTINUE READING
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