Effect of dietary protein on in vivo insulin action and liver glycogen repletion.

@article{Rossetti1989EffectOD,
  title={Effect of dietary protein on in vivo insulin action and liver glycogen repletion.},
  author={Luciano Rossetti and Douglas L. Rothman and Ralph A DeFronzo and Gerald I Shulman},
  journal={The American journal of physiology},
  year={1989},
  volume={257 2 Pt 1},
  pages={E212-9}
}
To investigate the influence of dietary manipulation on in vivo glucose metabolism, we pair fed normal rats for 10 days with one of three diets: 1) high protein-low carbohydrate (Hi-PN) (n = 20); 2) intermediate protein (I-PN) (n = 11); and 3) low protein-high carbohydrate (Lo-PN) (n = 18). Fasting glucose, postmeal plasma glucose, and insulin concentrations were as follows: 118 +/- 2 mg/dl, 138 +/- 2 mg/dl, and 4.0 +/- 0.2 ng/ml in Hi-PN; 111 +/- 3 mg/dl, 147 +/- 3 mg/dl, and 5.1 +/- 0.3 ng/ml… CONTINUE READING

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Dietary restriction in moderately obese rats improves body size and glucose handling without the renal and hepatic alterations observed with a high-protein diet.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme • 2015
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