Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells.

@article{Nelson1999EffectOD,
  title={Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells.},
  author={Kasey C Nelson and Joanne L Carlson and Michelle L Newman and Paul Sternberg and D. H. P. Jones and Terrance J Kavanagh and Dolores D{\'i}az and Jiyang Cai and M W Wu},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 9},
  pages={1927-35}
}
PURPOSE To determine the effect of dimethylfumarate (DMF), an inducer of glutathione (GSH)-dependent detoxification, on intracellular GSH levels in cultured human retinal pigment epithelium (hRPE) cells, its mechanism of action, and its effect on hRPE cells subjected to oxidative injury. METHODS Established hRPE cell lines were treated with DMF and… CONTINUE READING