Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism

@article{Thornton2008EffectOD,
  title={Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism},
  author={Sheila J. Thornton and Evelyn Wong Wong and Stephen D. Lee and Kishor Madanlal Wasan},
  journal={Lipids in Health and Disease},
  year={2008},
  volume={7},
  pages={21 - 21}
}
Pgp (P-glycoprotein, MDR1, ABCB1) is an energy-dependent drug efflux pump that is a member of the ATP-binding cassette (ABC) family of proteins. Preliminary studies have reported that nonspecific inhibitors of Pgp affect synthesis and esterification of cholesterol, putatively by blocking trafficking of cholesterol from the plasma membrane to the endoplasmic reticulum, and that relative increases in Pgp within a given cell type are associated with increased accumulation of cholesterol. Several… CONTINUE READING
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Regulation of Intestinal Cholesterol Absorption

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  • Annual Review of Physiology
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