Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species).

@article{Kushwaha1995EffectOD,
  title={Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species).},
  author={Rampratap S. Kushwaha and B Guntupalli and Karen S Rice and Kendall D Carey and Henry C. McGill},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1995},
  volume={15 9},
  pages={1404-11}
}
Our studies of baboons with low and high responses to dietary cholesterol and fat suggest that low-responding baboons increase the activity of hepatic sterol 27-hydroxylase, an important enzyme of bile acid synthesis, considerably more than do high-responding baboons when challenged with a high-cholesterol, high-fat (HCHF) diet. The present studies were conducted to determine whether hepatic sterol 27-hydroxylase mRNA levels and plasma 27-hydroxycholesterol concentrations also differed with… CONTINUE READING