Effect of diet on incidence of diabetes in nonobese diabetic mice.

@article{Coleman1990EffectOD,
  title={Effect of diet on incidence of diabetes in nonobese diabetic mice.},
  author={Douglas L. Coleman and J E Kuzava and Edward H. Leiter},
  journal={Diabetes},
  year={1990},
  volume={39 4},
  pages={432-6}
}
Nonobese diabetic/Lt mice exhibit a diabetes incidence greater than 70% in females at 30 wk of age. In studies designed to see whether increased dietary carbohydrate, fat, or protein influenced the severity or age at onset of the syndrome, we fed semipurified AIN-76 diet adulterated with increased amounts of these ingredients. Surprisingly, all AIN-76-based diets greatly reduced the expected incidence of diabetes at 30 wk. In addition, a hypoallergenic infant formula, Pregestimil, containing… CONTINUE READING