Effect of diazepam on plasma gamma-aminobutyric acid in sons of alcoholic fathers.

@article{Cowley1996EffectOD,
  title={Effect of diazepam on plasma gamma-aminobutyric acid in sons of alcoholic fathers.},
  author={Deborah S Cowley and Peter Paul Roy-Byrne and David J Greenblatt and Gerald L. Kramer and Frederick C. Petty},
  journal={Alcoholism, clinical and experimental research},
  year={1996},
  volume={20 2},
  pages={
          343-7
        }
}
A subgroup of abstinent alcoholics, display low levels of plasma gamma-aminobutyric acid (GABA). Two previous studies of plasma GABA in sons of alcoholic fathers (SOAs) have yielded conflicting results. The aim of the current study was to measure plasma GABA both at baseline and after challenge with diazepam, a GABAA receptor agonist, in a group of SOAs already shown to display decreased eye movement, memory, and sedative effects of diazepam. Twenty-seven SOAs and 23 male control subjects… CONTINUE READING