Effect of diabetes and aging on carboxymethyllysine levels in human urine.

  title={Effect of diabetes and aging on carboxymethyllysine levels in human urine.},
  author={K J Knecht and Jim Dunn and K F Mcfarland and David R. McCance and Timothy J Lyons and Suzanne R. Thorpe and John W. Baynes},
  volume={40 2},
Carboxymethyllysine (CML) has been identified as a modified amino acid that accumulates with age in human lens proteins and collagen. CML may be formed by oxidation of fructoselysine (FL), the Amadori adduct formed on nonenzymatic glycosylation of lysine residues in protein, or by reaction of ascorbate with protein under autoxidizing conditions. We proposed that measurements of tissue and urinary CML may be useful as indices of oxidative stress or damage to proteins in vivo. To determine the… CONTINUE READING
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