Effect of dexamethasone on transport of alpha-aminoisobutyric acid and sucrose across the blood-brain barrier.

@article{Ziylan1988EffectOD,
  title={Effect of dexamethasone on transport of alpha-aminoisobutyric acid and sucrose across the blood-brain barrier.},
  author={Yusuf Ziya Ziylan and J. M. Lefauconnier and Genevi{\`e}ve Bernard and J. M. Bourre},
  journal={Journal of neurochemistry},
  year={1988},
  volume={51 5},
  pages={1338-42}
}
The effect of glucocorticoids on the blood-brain barrier (BBB) was studied in rats following a single injection or 3 days of dexamethasone administration. Tracers with a low permeability across the intact endothelium, [14C]sucrose and alpha-[3H]aminoisobutyric acid ([3H]AIB), were simultaneously injected intravenously in untreated rats or in rats treated with dexamethasone. Unidirectional blood-to-brain transfer constants (Ki) in 14 regions of the rat brain were determined. In regions of… CONTINUE READING