Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .

@article{Lin1999EffectOD,
  title={Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .},
  author={Jiunn Huei Lin and Masato Chiba and I Wen-Peter Chen and J A Nishime and F A Deluna and Masayo Yamazaki and Yuh Jeng Lin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 10},
  pages={1187-93}
}
Indinavir, a potent and specific inhibitor of HIV protease, is a known substrate of cytochrome P-450 (CYP) 3A and p-glycoprotein. The purpose of this study is to investigate and compare the inducing effect of dexamethasone (DEX) on CYP3A and p-glycoprotein in the hepatic and intestinal first-pass metabolism of indinavir in rats. Pretreatment of rats with DEX had little effect on the pharmacokinetics (Cl and T(1/2)) after i.v. administration of indinavir, whereas DEX markedly altered the peak… CONTINUE READING