Effect of dexamethasone on nitric oxide synthase and Caspase-3 gene expressions in endotoxemia in neonate rat brain.

@article{Wang2005EffectOD,
  title={Effect of dexamethasone on nitric oxide synthase and Caspase-3 gene expressions in endotoxemia in neonate rat brain.},
  author={Hua Wang and Yu-bin Wu and X X Du},
  journal={Biomedical and environmental sciences : BES},
  year={2005},
  volume={18 3},
  pages={
          181-6
        }
}
OBJECTIVE To investigate the gene and protein expressions of three isoforms of nitric oxide synthase (NOS) and gene expression of Caspase-3, and effect of dexamethasone on them in neonatal rats with lipopolysaccharide (LPS)-induced endotoxemic brain damage. METHODS Expressions of the three isoforms of NOS and caspase-3 mRNA in the brain were investigated by RT-PCR in postnatal 7-day Wistar rats with acute endotoxemia by intraperitoneal administration of LPS. Regional distributions of NOSs… CONTINUE READING
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