Effect of dexamethasone and prednisolone on insulin-induced activation of protein kinase C in rat adipocytes and soleus muscles.

@article{Ishizuka1995EffectOD,
  title={Effect of dexamethasone and prednisolone on insulin-induced activation of protein kinase C in rat adipocytes and soleus muscles.},
  author={Takao Ishizuka and Masahide Yamamoto and Takeyuki Nagashima and Kazuo Kajita and Osamu Taniguchi and Keigo Yasuda and Kenji Miura},
  journal={Metabolism: clinical and experimental},
  year={1995},
  volume={44 3},
  pages={298-306}
}
We examined the effect of glucocorticoids on [3H]2-deoxyglucose ([3H]2-DOG) uptake, [125I]insulin binding, tyrosine kinase activity, and protein kinase C (PKC) activity in rat adipocytes and soleus muscles. In adipocytes, insulin-stimulated [3H]2-DOG uptake was decreased by prior 60-minute treatment with dexamethasone (DEX) or prednisolone (PSL), whereas [125I]insulin binding, insulin (INS) receptor autophosphorylation, and tyrosine kinase activity, as measured using exogenous substrate of poly… CONTINUE READING

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