Effect of developed tension on the time courses of Ca2+ transients and tension in twitch contraction in ferret myocardium.

@article{Komukai1996EffectOD,
  title={Effect of developed tension on the time courses of Ca2+ transients and tension in twitch contraction in ferret myocardium.},
  author={Kimiaki Komukai and Satoshi Kurihara},
  journal={Cardiovascular research},
  year={1996},
  volume={32 2},
  pages={384-90}
}
OBJECTIVES The aim of the study is to test the hypothesis that tension-dependent change in the affinity of cardiac troponin-C influences the time courses of Ca2+ transients and tension in twitch contraction. METHODS The Ca(2+)-sensitive photoprotein, aequorin, was microinjected into superficial cells of ferret papillary muscles and the Ca2+ transients and tension were simultaneously measured. The peak of developed tension was altered by changing the extracellular Ca2+ concentration, initial… CONTINUE READING

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